| Bioactivity | fac-[Re(CO)3(L3)(H2O)][NO3] (compound 3), the rhenium(I) tricarbonyl aqua complex, is an anticancer agent associated with mitochondrial dysfunction. fac-[Re(CO)3(L3)(H2O)][NO3] is cytotoxic to prostate cancer cells with IC50=0.32 μM (PC-3 cells). fac-[Re(CO)3(L3)(H2O)][NO3] mainly accumulates in mitochondria, down-regulates ATP production in PC3 cells, and promotes paraptosis. However, fac-[Re(CO)3(L3)(H2O)][NO3] did not induce necrosis, apoptosis and autophagy[1]. |
| In Vivo | fac-[Re(CO)3(L3)(H2O)][NO3] |
| Name | fac-[Re(CO)3(L3)(H2O)][NO3] |
| Formula | C25H17N6O8Re |
| Molar Mass | 715.64 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Enslin LE, et al. Rhenium(I) Tricarbonyl Complexes of 1,10-Phenanthroline Derivatives with Unexpectedly High Cytotoxicity. Inorg Chem. 2023 Aug 7;62(31):12237-12251. |
fac-[Re(CO)3(L3)(H2O)][NO3]
CAS: F: C25H17N6O8Re W: 715.64
fac- (compound 3),the rhenium(I) tricarbonyl aqua complex, is an anticancer agent associated with mitochondrial dysfunct
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